The Freilich Lab

Our projects

 
The main focus of the group is the study of metabolism in complex systems. Up to date, metabolic-driven analyses probably provide the most informative approach for integrating large-scale discrete information (genomic/transcriptomic/metabolomic) into a system-level description of cellular activity.
 
At my research, I've applied metabolic-driven approaches to explore the division of tasks within complex systems.  That includes the division of metabolic functions between animals' cells, promoting the specialization of cell-types and tissues. Similarly, division of metabolic tasks is also observed within bacterial communities. My recent research concerns understanding how cooperation and competition, both described systematically through the use of metabolic modeling, shape bacterial communities.
In the lab we will use metabolic driven analyses to continue the construction of interaction models in bacterial communities. We will also work together with other groups at Newe-Ya'ar to explore metabolic aspects of intra-population diversity in crop. 

 

Key projects in the lab include:

The educated design of bacterial communities towards improved bioremediation and bio-production and the rational design of probiotic administration. In a recent project we've  shown that metabolic-modeling can be applied for the systematic description of inter-species interactions and for the delineation of assembly principles of natural communities. We will continue this research where we aim to use computational simulations for the successful design of desired bacterial communities (considering community's function and structure).



Using next generation sequencing for developing improved plant traits. Next generation sequencing approaches together with metabolomic phenotyping are extensively used at Neve-Ya'ar for the study of intra-population diversity in crop. We plan to focus on the study of metabolic aspects of diversity, as part of the quest for improved plant traits.